Deregulation of purine metabolism in Alzheimer's disease

Study of Purine Metabolism

A B S T R A C T A case of xanthinuria is briefly described, and the results of in vivo studies with 4C-labeled oxypurines are discussed. The data demonstrate that the rate of the turnover of uric acid is normal, despite an extremely small uric acid pool. Xanthine and hypoxanthine pools were measured and their metabolism evaluated. The bulk of the daily pool of 276 mg of xanthine, but only 6% of...

Glucose Role in Treatment of Alzheimers’ Disease

1. Dong H, Csernansky JG (2009) Effects of Stress and Stress Hormones on Amyloidβ Protein and Plaque Deposition. J Alzheimers Dis 18: 459-469. 2. Csernansky JG, Dong H, Fagan AM, Wang L, Xiong C, et al. (2006) Plasma cortisol and progression of dementia in subjects with Alzheimer‐ type dementia. Am J Psychiatry 163: 2164-2169. 3. Swaab DF, Raadsheer FC, Endert E, Hofman MA, Kamphorst W, et al. ...

Purine metabolism in Trichomonas vaginalis.

The purine metabolism of several genera of parasitic protozoa, is of interest partly due to their sensitivity to purine analogues, and to differences in the enzymes of purine metabolism compared to mammalian systems [l-6]. Trichomonas vaginalis, the causative agent of trichomonal vaginitis, a mild, but very common, sexually-transmitted disease, has not been studied in this respect; there is a g...

Lix. Studies in Purine Metabolism

Current State of Alzheimers Disease Research Therapeutics

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